Estimates of cancer risk are variable across different studies; nevertheless, two large meta-analyses, resulting from a total of 31 published studies, estimated an OC risk to age 70 of 49% for BRCA1 and 18% for BRCA2 [96] and of 39% for BRCA1 and 11% for BRCA2 [97]. The gene discussed is BRCA1; the disease is cancer.