The tumor stroma of BALB-neuT mice is infiltrated by CD4 and CD8 T lymphocytes and a few B, natural killer (NK), and γδ T lymphocytes, but mostly by regulatory T (Tregs) cells, myeloid derived suppressor cells (MDSCs), and tumor associated macrophages (TAMs) that are recruited into TME in response to inflammatory molecules and cytokines being released in the tumor milieu [105, 106]. Here, CD4 is linked to neoplasm.