CCL2 and neoplasm: Similar IL-6-dependent upregulation is observed in the chemokine (C-C motif) ligand (CCL) 2 (also known as monocyte chemotactic protein-1, MCP-1), whose production is induced by IL-6 in both tumor cells and stromal cells and that supports the expansion of the CSC compartment by activating the Notch1 signaling pathway [70].