ERBB2 and breast carcinoma: This observation has paved the way for the development of new immunologically based therapies against neoplastic cells that overexpress HER2, which have made some important clinical achievements [15]; the U.S. Food and Drug Administration (FDA) has approved mAbs that target HER2, such as Trastuzumab and Pertuzumab, and several drugs (i.e., TDM1 and ARRY-380) [16], which have prolonged the disease-free survival rates in patients with metastatic HER2 positive breast cancer [17] and are currently under investigation in clinical trials.