CCL2 and cancer: We demonstrated, by microarray analysis, that CCL2 expression increases in BALB-neuT mice as carcinogenesis progresses [71], and its causal role in cancer development was further supported by the observation that BALB-neuT mice, which were knocked-out (KO) for CCL2, displayed prolonged survival over BALB-neuT mice wild-type (WT) for this chemokine [72].