IL17A and autoimmune myocarditis: Furthermore, previous study found that the elevated expressions of osteoprotegerin (OPG) and receptor activator of nuclear factor-κB ligand (RANKL) in experimental autoimmune myocarditis (EAM) induced heart dysfunction rat model, and anti-IL-17 treatment could change the expressions of OPG and RANKL in ISO induced adult heart dysfunction rat model [28, 29].