From 2000, Tracey and colleagues have been working on the mechanisms by which electric stimulation of vagus nerve suppresses activation of NF-κB and production of proinflammatory cytokines in α7 nicotinic acetylcholine receptor- (α7 nAChR-) expressing macrophages and lessens severity of sepsis in animal models [1, 2]. Here, NFKB1 is linked to Sepsis.