This is an interesting finding, since upregulation of the prosurvival proteins Bcl-2 and Bcl-2XL has been described in recurrent GBMs independent of treatment [39] and overexpression of Bcl-2 or Bcl-XL not only leads to resistance to apoptosis but also has been linked to increased GBM cell motility [40]. The gene discussed is BCL2L1; the disease is glioblastoma.