He received urgent palliative radiotherapy to a dose of 20 Gy in 5 fractions at levels T2–T5 and T12–L5 and he started palliative chemotherapy with docetexal on a 3-weekly basis (first 3 cycles with 75 mg/m2 and as he tolerated it well, the dose was escalated to 100 mg/m2) along with trastuzumab (loading dose of 8 mg/kg followed by 6 mg/kg on a 3-weekly basis) since the tumour was Her2 positive. The gene discussed is ERBB2; the disease is neoplasm.