This hypothesis is supported by the finding that inclusions isolated from postmortem brain tissue from patients with FXTAS contain FMR1 mRNA and over 30 proteins, many critical for normal cell function, such as lamin A/C, γH2AX, Sam 68, drosha, Ku86 and hnRNPA2 [17-19]. Here, XRCC5 is linked to fragile X-associated tremor/ataxia syndrome.