PIK3C2A and Abnormal renal physiology: METH increased significantly creatinine and creatinine phosphokinase (CPK), while serum minerals, potassium, calcium, and phosphorus levels decreased, so METH induced renal dysfunction with renal tubule damage; this damage is related to leakage of CPK from the skeletal muscle as an index of skeletal muscle damage following METH injections, also oxidative DNA damage was induced by repeated administration of METH [21].