Third, this study showed reduced levels of OPG and higher levels of sRANKL and sRANKL/OPG ratio in patients with epilepsy, the duration of treatment with AEDs were positively correlated with sRANKs and negatively correlated with OPG, BMD at the femoral neck, and lumbar spine and serum levels of sRANKL and OPG and in linear regression analysis and after adjusting for gender, age, weight, duration of therapy, and number of AEDs, we observed an association between BMD, 25(OH)D, and sRANKL concentrations. The gene discussed is TNFRSF11B; the disease is epilepsy.