MAPK8 and age-related macular degeneration: As shown in Figure 6E, western blotting data demonstrated that the phospho-JNK1/2 protein levels in the H2O2-stimulated AMD-RPEs pre-treated with curcumin were significantly lower than those in the H2O2-stimulated AMD-RPEs without curcumin pre-treatment, and the total form JNK was not affected.