FBXO3 and acute lymphoblastic leukemia: The other proteins which were implicated in cellular metabolic pathways (i.e., cystein desulfurase alpha (CDSα), pyruvate deshydrogenase E1 (PDH-E1), cat eye syndrome critical region protein 5 (CECR5), isovaleryl CoA deshydrogenase (IVAD) and fructose biphosphate aldolase (FBA)) were all together predominant in the group of pre-B2 ALL without t(12;21) (p < 0.005, p < 0.005, p < 0.01, p < 0.01, p < 0.01, respectively).