CNN2 and acute lymphoblastic leukemia: Among the proteins involved in cell cycle regulation, are the calponin-2 (CNN2) and methionine adenosyltransferase 2beta (MAT2β) variant 1, which are highly expressed in ALL with t(12;21), usually associated to good prognosis (p < 0.001, with a power of 0.998; p < 0.005, with a power of 0.985, respectively) (see Table 2).