CD4 and colitis: In this study, we determined the effect of antagonizing AA-derived eicosanoids on local [colon and mesenteric lymph node (MLN)] and systemic (splenic) levels of the relevant CD4+ T cell effector subsets (Th17, Th1, Th2, and Tregs) and Th17 cell-mediated colonic cytokine expression in response to TNBS-induced colitis.