Exposure to HF throughout pregnancy increased the hepatic gene expression of insulin-like growth factor 1 (IGF1) (p < 0.0001), insulin-like growth factor 1 receptor (IGF1R) (p < 0.001), and insulin-like growth factor binding protein 1 (IGFBP1) (p < 0.0001), genes involved in fetal growth when compared to the C diet. The gene discussed is IGFBP1; the disease is hydrops fetalis.