SIRT1 and hydrops fetalis: Hepatic GSK3a (p < 0.01) and SIRT1 (p < 0.01) gene expression were significantly elevated in the HF fetuses when compared to HF-C group (Figure 3).Exposure to a HF diet during the second half of pregnancy (C-HF) significantly increased the hepatic gene expression of G6Pase (p < 0.01), GSK3a (p < 0.01), and SIRT1 (p < 0.01) when compared to a C diet.