Exposure to a HF diet throughout pregnancy (HF) significantly increased the expression of hepatic genes associated with inflammation such as nuclear factor kappa B 1 (NFKB1) (p < 0.001), heme oxygenase 1 (HMOX1) (p < 0.001), musculoaponeurotic fibrosarcoma oncogene homolog F (MAFF) (p < 0.001), cytokine signaling protein 3 (SOCS3) (p < 0.01), dual specificity protein phosphatase 1 (DUSP1) (p < 0.01), and inhibitor of DNA binding 1 (ID1) (p = 0.0001) when compared to a C and HF-C diet. The gene discussed is DUSP1; the disease is hydrops fetalis.