Furthermore, ANA, anti-SSA/Ro antibodies (SSA), anti-SSB/La antibodies (SSB), anti-double stranded DNA antibodies (Ds-DNA), anti-nucleosome antibody (AnuA), anti-Sm antibodies (Sm) seropositivity, and serum IgG were significantly lower in NMOSD patients without autoimmune diseases than in NMOSD patients with autoimmune diseases (p < 0.05), while anti-thyroglobulin antibodies (TG) seropositivity, thyroxin (T4), and free thyroxin (FT4) were significantly higher in NMOSD patients with autoimmune diseases (p < 0.05). The gene discussed is CALR; the disease is autoimmune disease.