ANA, SSA, SSB seropositivity was significantly higher in NMOSD patients with non-organ-specific autoimmune diseases than in NMOSD patients with organ-specific autoimmune diseases (p < 0.05), while anti-thyroid peroxidase antibodies (TPO) and TG seropositivity was significantly lower in NMOSD patients with non-organ-specific autoimmune diseases than in NMOSD patients with organ-specific autoimmune diseases (p < 0.05). This evidence concerns the gene CALR and autoimmune disease.