In the present study the urinary concentrations of both MMP3 and MMP9 were much higher in non schistosomal bladder cancer patients than in schistosomal ones and these findings are different from those of Fouda et al., who reported that there was no significant increase in MMP-9 activity in bilharzial related TCC type compared to non bilharzial one [19]. This evidence concerns the gene MMP9 and urinary bladder cancer.