Because a little is known on association of hMSH2 genetic variants and triple-negative breast carcinoma, we studied whether two polymorphisms of this gene: an A/G transition at 447 position producing an Asn/Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G/A transition at 1032 position resulting in a Gly/Asp change at codon 322 (the Gly322Asp polymorphism) may be linked with TNBC risk in Polish women. This evidence concerns the gene MSH2 and triple-negative breast carcinoma.