DNAH5 and chronic obstructive pulmonary disease: Our meta-analysis of three GWASs of TLCCT in subjects with moderate-to-severe COPD has found a genome-wide significant region on chromosome 5p15.2, containing the gene DNAH5 and several suggestive loci on chromosomes 8q24, 19p13, and 6q13, with P values < 5 × 10−7.