In addition to the regulatory effects of Sirt1 and Sirt6 on diabetes and hepatic steatosis, other sirtuins including Sirt2 and Sirt3 also demonstrate the possibility of acting as metabolic regulators [21]–[23], which suggests that sirtuins’ actions on metabolism seem to be, in part, overlapping and redundant. This evidence concerns the gene SIRT1 and fatty liver disease.