To account for the results we observed, we hypothesize that marked, but incomplete reduction of HSP or HIF-1a may be insufficient to induce complete tumor destruction at 24 hr and that, the ability of each drug to increase local coagulation may be susceptible to a threshold effect, with only a certain amount of drug required to target the partially injured remaining cells in the periablational rim. The gene discussed is HSP90B2P; the disease is neoplasm.