HMGB1 and cancer: While three of the chimeras (ACTB->POTEM, ACTB->POTEE and SP100->HMGB1) have been found in normal population [35], [36], three of the chimeras (C2orf27A->NBEA, HILPDA->EFCAB3, FARSB->TRIM61) were previously identified only in cancer samples [37].