Likewise, in the second affected family, two cancer patients (the proband who was diagnosed with CRC at the age of 54 years and his brother who was diagnosed with renal cancer at the age of 49) and 8 healthy individuals (mean age 32 years) were heterozygous for the large deletion encompassing exon 13 of the MLH1 gene. The gene discussed is MLH1; the disease is colorectal carcinoma.