There was also a greater frequency of splenomegaly in IL-17A−/−IL-2Rα−/− mice (8/22) compared to IL-2Rα−/− mice (0/17) and IFN-γ−/−IL-2Rα−/− mice (0/11) (Figure 3A). The gene discussed is IL2RA; the disease is Splenomegaly.