Accordingly, a 5-year prospective follow-up study evaluated the immunological status and evolution of 134 children who were born to mothers with APS and found no instances of thrombosis or systemic lupus erythematosus despite the presence of lupus anticoagulant (4%), IgG anti-cardiolipin antibodies (16%), and IgG and IgM anti-β2GPI 15% and 3%, respectively [28]. This evidence concerns the gene APOH and autoimmune polyendocrinopathy.