The possible roles of antiphospholipid (aPL) in the pathogenesis of thrombosis in APS are well established in the scientific literature, including changes in the coagulation cascade, including inhibition of protein molecules C, antithrombin, and annexin, platelet activation and complement, and increased expression of endothelial adhesion molecules [3]. The gene discussed is FASLG; the disease is Venous thrombosis.