Although allergy-associated TH2 responses and antihelminthic TH2 responses are very similar, they also differ as follows: (1) larger amounts of polyclonal, non-parasite-specific IgE antibodies are produced that do not cause allergic reactions and (2) during helminth infection an induction of strong inflammatory regulatory immune responses occurs [25, 26]. This evidence concerns the gene IGHE and helminthiasis.