The myenteric plexus may be infiltrated directly or attacked by host's immune system that creates autoantibodies in response to surface tumour antigens that can cross-react leading to nerve injury and damage [19, 20] Achalasia has also been reported due to antineuronal antibodies (anti-Hu, anti-Yo, and N-type Ca2+ channel antineuronal antibodies) especially in patients with small cell lung cancer [21, 22]. Here, CDR2 is linked to Achalasia.