MYD88 mutations have since emerged in a number of other human malignancies, with the L265P mutation found in including almost 100% of Waldenström’s macroglobulinemia (WM), 2–10% of chronic lymphocytic leukemia (CLL), 69% of cutaneous diffuse large B cell lymphoma (CBCL), and 38% of primary central nervous system lymphoma (PCNSL) (previously reviewed in Ref. This evidence concerns the gene MYD88 and primary central nervous system lymphoma.