Overexpression of VCP mutants linked to MSP and ALS did not inhibit the UPS (Tresse et al., 2010), whereas some of the VCP-mediated events mentioned above were altered (Ju et al., 2009; Tresse et al., 2010; Bartolome et al., 2013; Fujita et al., 2013; Kim et al., 2013), suggesting that the pathology caused by mutant VCP likely involves essential ubiquitin-dependent processes that are different from proteasomal degradation. The gene discussed is VCP; the disease is amyotrophic lateral sclerosis.