In particular, mutations in the PSMB8 gene, located at the locus 6p21 and codifying the inducible subunit β type-8 (PSMB8) of the proteasome, have been identified as the cause of Nakajo-Nishimura syndrome [99–101], recently redefined as “Japanese autoinflammatory syndrome with lipodystrophy” [102] and known in Western countries as “joint contractures, muscle atrophy, and panniculitis-induced lipodystrophy syndrome” (or JMP) [103, 104]. Here, PSMB8 is linked to lipodystrophy.