PSMB8 and proteosome-associated autoinflammatory syndrome: CANDLE syndrome has been also described as distinct from NNS, though determined by missense mutations of the same PSMB8 gene and other proteasome-associated genes [105]; it starts during the first year of life with recurrent fevers as high as 42°C, lymphadenopathy, arthralgia, purplish eyelid edema, abnormal growth of lips, and progressive lipodystrophy [111].