NLRP12 and Alzheimer disease: NLRP12-associated autoinflammatory disorder (NLRP12-AD) is a rare autosomal-dominant condition, firstly observed in two families originating from Guadeloupe, who presented a nonsense mutation in the NLRP12 gene, situated at the locus 19q13.4, encoding the monarch-1 protein, which is mainly expressed in monocytes and is involved in the activation of NF-κB protein complex via canonical and noncanonical pathways [65, 66].