CD8A and malaria: As described above, the immunodominant T-cell epitope of the PyCS protein, SYVPSAEQI, is presented by H-2Kd molecules to CD8+ T cells and is known to be the only epitope that can induce protective CD8+ T cells against malaria [10, 11], underscoring the importance of generating MHC-I-Kd-Tg mice.