NW‐LDH, NW‐caspase 3/7 and NW‐LDH/NW‐caspase 3/7 ratio and their interactions with demographic factors are predictive of bronchiolitis severity and can help distinguish children requiring ICU‐level care from those admitted to the general floor, or discharged home from the emergency center. Here, CASP3 is linked to bronchiolitis.