Interestingly, in our study, NAb VRC01 that recognizes the CD4 binding site (CD4bs) of the gp12038 and polyclonal IgG (that probably contains a large number of anti-CD4bs Ab)39, had almost no effect on IFN-α production by primary pDC while they inhibited the productive infection of the cells. The gene discussed is CD4; the disease is infection.