EDN1 and ovarian carcinoma: β-Arrestin-1 has also been found to be a nuclear transcriptional regulator of ET–1-induced β-catenin signalling, an important mechanism for controlling cell division and progression of epithelial ovarian cancer and necessary for epigenetic modification, such as histone acetylation, and gene expression (Rosanò et al., 2009; 2013a,).