MAPT and Alzheimer disease: The “amyloid cascade hypothesis”, currently the prevailing hypothesis regarding AD pathogenesis, states that Aβ-42 peptides aggregate to form toxic Aβ-42 oligomers and plaques, which then trigger a cascade of neuropathological events, including neuroinflammation, oxidative stress, tau hyperphosphorylation and NFT formation, and, ultimately, widespread neurodegeneration and dementia [2].