CELSR1 and craniorachischisis: A cross between ScribCrc/+ and a second Celsr1 mutant allele, spin-cycle (Curtin et al., 2003) also generated doubly heterozygous fetuses with isolated craniorachischisis (n=10/18; Fig. 2N), or craniorachischisis with abdominal wall defect (n=1/18; Fig. 2O), as well as eyelid closure defects (n=2/2; Fig. 2N,O).