Raf Kinase Inhibitory Protein (RKIP), a member of the phosphatidylethanolamine binding protein (PEBP) family, is widely expressed in normal human tissues, highlighting its role in various physiologic processes [25], but is considered to be a metastasis suppressor in cancer, being its loss or reduced expression associated with malignancy and prognosis in many types of metastatic and aggressive cancers [26–29]. The gene discussed is PEBP1; the disease is cancer.