MiR-27a modulated MDR1/P-glycoprotein expression in human ovarian cancer cells by targeting HIPK2 [23] and Down-regulation of miR-27a might reverse multidrug resistance of esophageal squamous cell carcinoma through regulation of MDR1 and apoptosis [24]. The gene discussed is HIPK2; the disease is esophageal squamous cell carcinoma.