For the individual components of the primary outcome, 12/31 (39%) versus 34/218 (16%) had progression of AKI stage (P = 0.002), and 10/31 (32%) versus 35/218 (16%) died in-hospital (P = 0.03), respectively.In regression analyses, the unadjusted odds ratio for the primary outcome with YKL-40 ≥ 5 ng/ml was 3.1 (1.4-6.6), and after adjusting for the variables in the clinical model, the odds ratio increased slightly to 3.4 (1.5-7.7). The gene discussed is CHI3L1; the disease is acute kidney injury.