This includes decreased uptake of acetylcholine and decreased activity of acetylcholinesterase, in accordance with reported decreases in levels and activity (respectively) in AD [36]; decreased secretion of norepinephrin, consistent with a previous metabolomic study showing its significant depletion in AD [37]; and decreased transport of 4-aminobutanoate (GABA) into the mitochondria. This evidence concerns the gene ACHE and Alzheimer disease.