GNAS and hepatocellular carcinoma: The prevalence and type of mutations detected are comparable to those expected in the diverse tumor types considered herein, as reported by the curated COSMIC database [18]: the CTNNB1 gene was always mutated in SPT and in 3 of 5 HCC [17], the R132 hotspot in IDH1 gene was identified for ICC [30], [31] and GNAS R201 for IPMN, KRAS was the most frequently mutated gene in pancreatic cancers while TP53 was frequently mutated in both pancreatic and gastric cancers [15], [32], [33].