CDH13 and hyperinsulinemic hypoglycemia, familial, 4: Finally, comparing genotype-stratified analyses in the SAPALDIA cohort, the size of effect modification by the CDH13 SNPs reported here on the PM10–FEF25–75% association is substantially smaller than the size of effect modification by SERPINA1 genotypes (underlying intermediate alpha 1 antitrypsin deficiency) on the association of FEF25–75% decline with occupational exposure to vapors, dusts, gases, and fumes (Mehta et al. 2012).