Compared with unaffected pregnancies, kisspeptin was significantly lower in women who experienced miscarriage when compared with unaffected pregnancies (Figure 3A); the lowest levels were observed in patients miscarrying during the first week after the blood measurement (kisspeptin in picomoles per liter: 2250 ± 1045, no miscarriage; 195 ± 116, miscarriage < 7 d, P < .001 vs no miscarriage). This evidence concerns the gene KISS1 and Miscarriage.