Combining the hCG and kisspeptin measurements as a predictive test for viability did not greatly improve the diagnostic accuracy achieved using kisspeptin alone, indicating that perturbation of kisspeptin secretion in our cohort of women ranging from 6 to 29 weeks of gestation was more frequently associated with miscarriage than changes in serum hCG concentration. The gene discussed is KISS1; the disease is spontaneous abortion.