BDNF and obesity due to melanocortin 4 receptor deficiency: No epigenetic studies have been performed on Rai1 haploinsufficient mice; however, our previous work has shown that Rai1 haploinsufficient mice have a basal decrease in Bdnf and Pomc expression and an increase in Mc4r expression, lending evidence to the global effects Rai1 alone has on obesity and weight pathways [11].