For instance, it may be meritorious to study superFVa in the setting of acute traumatic coagulopathy where recent evidence suggests that early bleeding may be exacerbated by endogenous APC generation [25]–[27], in hemophilia where inhibitor formation against exogenous FVIII or FIX requires alternative hemostatic treatments, or for reduction of bleeding associated with (novel oral) anticoagulants. The gene discussed is F8; the disease is blood coagulation disease.