Although our results are different from an earlier study which reported loss of protection by sevoflurane postconditioning in the prediabetic state of the leptin-mutant Zucker obese rat model [53], the fact that protection in this model could not be rescued by cyclosporine A, a mPTP opener, points to severe downstream defects associated with this genetic mutant, which may not necessarily reflect conditions in early diabetes. Here, LEP is linked to diabetes mellitus.