CCN2 and Cirrhosis: Subsequent multivariable analysis indicated background cirrhosis (HR = 1.815, P = 0.004) and vascular invasion (HR = 1.764, P = 0.015) as independent prognostic factors for DFS after surgery; CCN2 expression was not significant in multivariate analysis (HR = 1.561, P = 0.056, Table 3).