CCN2 and Cirrhosis: Univariable analysis revealed background cirrhosis (P = 0.002), large tumor size (≥5 cm) (P = 0.001), high Edmondson grade (P = 0.007), vascular invasion (P<0.001), multiple tumors (P<0.001), tumor stage III/IV (P<0.001), and CCN2 expression (P = 0.005) to be adverse prognostic factors for DFS after surgery.