Morphoproteomic analysis of his primary tumor specimen revealed expression of p-ERK1/2 (focal and variable expression of the ERK pathway as evidenced by the expression and nuclear translocation of p-ERK1/2), activation of the p-mTOR pathway, expression of HSP90, and expression of TRAIL, NESTIN, and insulin-like growth factor 1 receptor (IGFR). Here, MAPK3 is linked to neoplasm.