In addition, keratinocytes in psoriasis as well as synoviocytes in RA are capable of responding to direct IL-36 ligands stimulation with production of IL-6, IL-8, and antimicrobial peptides, which cooperate with IL-17A and TNF-alpha promoting neutrophil activation and migration [11, 54, 56, 60]. This evidence concerns the gene TNF and psoriasis.