IL36RN and acquired polycythemia vera: Primary epidermal IL-36 overexpression in transgenic mouse models results in PV-like phenotype histopathologically characterized by acanthosis, hyperkeratosis, and mixed inflammatory infiltration with predominance of neutrophils [55, 59]; further crossing with IL36RN-knockout strain augments IL-36 signaling leading to increased neutrophil infiltration and a histopathological picture more akin to classic PP [25, 55, 61].