To date, T-cell epitopes derived from several glioma-associated antigens have been shown to elicit T-cell responses against gliomas of several genes, including SART-1 and -3, interleukin-13 receptor a2 chain, ARF4L, GALT3, AIM-2, EphA2, EGFRvIII, HER-2, gp100, MAGE-1, glioma big potassium (gBK), TRP-2, SOX2, SOX11, SOX6, and 3′  β-hydroxysteroid dehydrogenase type 7 gene [12, 24, 35–50]. The gene discussed is PMEL; the disease is central nervous system cancer.