The M2 phenotype macrophages induced by transforming growth factor (TGF-β1) and inflammatory factors, such as interleukin- (IL-) 4 and IL-10, produce high amount of collagen VI. In vitro studies showed also that macrophages use collagen VI to modulate their binding properties rather than to build native ECM as do other cell types, including fibroblasts and smooth muscle cells (SMC), suggesting TAMs as one of the key providers for collagen VI in tumours. Here, IL10 is linked to neoplasm.