High concentrations of adenosine could blunt the capacity of nature killer (NK) cells to produce tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) and also inhibit the lytic activity of NK cells in an A2A receptor dependent manner, thus limiting the ability of NK cells to mediate the lysis of tumor cells [54]. The gene discussed is TNF; the disease is neoplasm.