Interestingly, Allard found that anti-CD73 mAb significantly enhanced the activity of both anti-CTLA-4 and anti-PD-1 mAbs against MC38-OVA (colon) tumor, RM-1 (prostate) subcutaneous tumors, and metastatic 4T1.2 breast cancer in mice models [73]. The gene discussed is CTLA4; the disease is neoplasm.